Investigating how to reduce aging effects in the lungs of cystic fibrosis patients
Epigenetic Modulation of Cellular Senescence in the Cystic Fibrosis Lung
This study is looking at how aging affects the lungs of people with cystic fibrosis and is exploring new ways to help improve lung health and quality of life by targeting the aging process in lung cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-11056706 on NIH RePORTER |
What this research studies
This research focuses on understanding how cellular aging affects the lungs of individuals with cystic fibrosis (CF). It aims to explore novel therapeutic strategies that can combat cellular senescence, a process that accelerates aging and worsens lung function in CF patients. By examining the role of specific proteins involved in gene regulation, the study seeks to identify potential treatments that could improve lung health and overall quality of life for those affected by CF. The research will involve laboratory experiments to analyze the epigenetic changes associated with aging in lung cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing accelerated aging effects in their lung function.
Not a fit: Patients without cystic fibrosis or those who do not exhibit signs of accelerated aging in their lungs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung function and quality of life for cystic fibrosis patients.
How similar studies have performed: Previous research has shown promise in using epigenetic approaches to improve lung function in cystic fibrosis, indicating that this area of study has potential for success.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Sanders, Yan — Old Dominion University
- Study coordinator: Sanders, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.