Investigating how to reduce aging effects in the lungs of cystic fibrosis patients
Official title: Epigenetic Modulation of Cellular Senescence in the Cystic Fibrosis Lung
Funded at Old Dominion University · NIH-11056706 · Data updated 2026-11-12
This study is looking at how aging affects the lungs of people with cystic fibrosis and is exploring new ways to help improve lung health and quality of life by targeting the aging process in lung cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $561,233 |
| NIH project number | 5R01HL169253-03 |
| Project ID | NIH-11056706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing accelerated aging effects in their lung function.
✕Less likely to help
Patients without cystic fibrosis or those who do not exhibit signs of accelerated aging in their lungs may not benefit from this research.
What this research studies
This research focuses on understanding how cellular aging affects the lungs of individuals with cystic fibrosis (CF). It aims to explore novel therapeutic strategies that can combat cellular senescence, a process that accelerates aging and worsens lung function in CF patients. By examining the role of specific proteins involved in gene regulation, the study seeks to identify potential treatments that could improve lung health and overall quality of life for those affected by CF. The research will involve laboratory experiments to analyze the epigenetic changes associated with aging in lung cells.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung function and quality of life for cystic fibrosis patients.
How similar studies have gone: Previous research has shown promise in using epigenetic approaches to improve lung function in cystic fibrosis, indicating that this area of study has potential for success.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Sanders, Yan — Old Dominion University
- Study coordinator: Sanders, Yan
Related research
Other NIH-funded projects on the same topics.
-
Blocking CFTR in the cervix to prevent conception without hormones
A non-hormonal approach aims to stop sperm from entering the uterus by making cervical mucus too thick for sperm, potentially offering a new contraception option.
-
Optimizing Treatments for People with Cystic Fibrosis on Highly Effective Modulator Therapy
A real-world study in people with cystic fibrosis on highly effective CFTR modulator therapy to understand how traditional CF treatments can be adjusted safely.
-
Elastin-like particles to deliver gene therapies for cystic fibrosis
A new nanoparticle system is being developed to deliver genetic therapies directly to the lungs of people with cystic fibrosis, including those with nonsense mutations.
-
Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS
A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.
-
Ceftaroline-meropenem combo to beat MRSA in cystic fibrosis
A new combination antibiotic approach is being tested to help people with cystic fibrosis who have MRSA infections that resist standard treatments.
-
Gut microbiome in cystic fibrosis and colorectal cancer risk
Researchers are studying how the gut bacteria in adults with cystic fibrosis influence the development of colorectal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.