Investigating how to protect the nervous system from aging effects
Official title: Homeostatic Neuroprotection in the Aging Nervous System
Funded at University of California, San Francisco · NIH-11001976 · Data updated 2026-11-12
This study is looking at how getting older affects our nerves and muscles, using mice to find ways to keep our muscles healthy as we age, which could help improve the health and quality of life for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $554,069 |
| NIH project number | 5R01AG081252-03 |
| Project ID | NIH-11001976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing age-related muscle decline or frailty.
✕Less likely to help
Patients who are younger than 21 or do not exhibit signs of age-related neuromuscular decline may not benefit from this research.
What this research studies
This research focuses on understanding how age-related changes in the nervous system affect muscle function and overall health. By studying mouse models, the researchers aim to uncover the molecular mechanisms that contribute to neuromuscular decline as we age. They will explore a concept called 'Homeostatic Neuroprotection,' which may help maintain muscle health and function despite the aging process. The findings could lead to new strategies for improving health and quality of life in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve muscle function and overall health in aging individuals.
How similar studies have gone: Previous research has shown promising results in using homeostatic mechanisms to maintain neuromuscular function, suggesting potential for success in this approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Davis, Graeme W — University of California, San Francisco
- Study coordinator: Davis, Graeme W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.