Investigating how to protect muscle function during sepsis
Targeting mitochondrial permeability transition to attenuate adverse muscle impact in sepsis
This study is looking at how sepsis can harm your muscles and make it harder to recover from serious illnesses, and it aims to find new ways to protect your muscles and help you heal better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10950721 on NIH RePORTER |
What this research studies
This research focuses on understanding how sepsis negatively affects skeletal muscle, which can lead to severe health issues such as difficulty in recovering from mechanical ventilation and increased mortality. The study explores a specific cellular event called mitochondrial permeability transition (mPT) that may contribute to muscle dysfunction and inflammation during sepsis. By examining the mechanisms behind mPT, the researchers aim to identify potential treatments that could mitigate muscle damage and improve overall patient outcomes. This approach involves studying the role of certain proteins and cellular processes in muscle cells during sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are experiencing muscle dysfunction.
Not a fit: Patients with sepsis who do not exhibit muscle-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve muscle function and reduce complications in patients suffering from sepsis.
How similar studies have performed: While the specific focus on mitochondrial permeability transition in skeletal muscle during sepsis is relatively novel, similar approaches have shown promise in other tissues affected by sepsis.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Hepple, Russell T — University of Florida
- Study coordinator: Hepple, Russell T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.