Investigating how to protect insulin-producing cells to prevent diabetes
Modulating intrinsic beta cell stress to block diabetes pathogenesis
This study is looking at how insulin-producing cells in the body handle stress and what happens when they don't work properly, with the hope of finding new ways to keep these cells healthy and prevent diabetes, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10843870 on NIH RePORTER |
What this research studies
This research focuses on understanding how beta cells, which produce insulin, cope with stress and how their dysfunction can lead to diabetes. By studying human beta cells and using advanced techniques like CRISPR, the researchers aim to identify the mechanisms that cause beta cell failure under stress. The goal is to find new therapeutic targets that can help maintain beta cell function and prevent the progression of diabetes. Patients may benefit from insights that could lead to innovative treatments for diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of developing Type 1 or Type 2 diabetes due to beta cell dysfunction.
Not a fit: Patients who already have advanced diabetes complications or those without beta cell involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect insulin-producing cells and prevent or delay the onset of diabetes.
How similar studies have performed: Other research has shown promise in targeting cellular stress responses to improve beta cell function, indicating a potential for success in this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Papa, Feroz R — University of California, San Francisco
- Study coordinator: Papa, Feroz R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.