Investigating how to prevent the degradation of a protein that helps regulate blood pressure.
Targeting ACE2 ubiquitination for hypertension
This study is looking at how a protein called ACE2 affects blood pressure in older adults with hypertension, and it hopes to find ways to keep this protein working well, which could lead to new treatments to help manage high blood pressure better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10534148 on NIH RePORTER |
What this research studies
This research focuses on hypertension, a condition affecting many older adults, and aims to explore the role of a protein called ACE2 in regulating blood pressure. The study investigates how ACE2 is degraded in the body and seeks to find ways to prevent this degradation, potentially leading to better management of hypertension. By understanding the mechanisms involved, the research hopes to develop new therapeutic strategies that could help maintain healthy blood pressure levels. Patients may benefit from innovative treatments that enhance ACE2 function and counteract the harmful effects of hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 55 and above, who are experiencing hypertension.
Not a fit: Patients who do not have hypertension or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively lower blood pressure and reduce the risk of cardiovascular diseases.
How similar studies have performed: Other research has shown promising results in targeting similar pathways for hypertension management, indicating potential for success in this approach.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Lazartigues, Eric D — Lsu Health Sciences Center
- Study coordinator: Lazartigues, Eric D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.