Investigating how to prevent aging-related issues in people with HIV
Official title: Reduction of the Beclin1-BCL2 complex in the prevention of HIV and comorbidities associated with aging
Funded at Florida International University · NIH-11085651 · Data updated 2026-11-12
This study is looking at how a certain protein complex affects aging problems in people with HIV, and it aims to find ways to help improve health and memory as they get older by testing on mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $222,000 |
| NIH project number | 1R21AG090170-01A1 |
| Project ID | NIH-11085651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are living with HIV and experiencing age-related cognitive decline.
✕Less likely to help
Patients who are not living with HIV or those who do not have age-related cognitive issues may not benefit from this research.
What this research studies
This research explores the relationship between a specific protein complex and aging-related complications in individuals living with HIV. By focusing on the Beclin1-Bcl-2 complex, the study aims to enhance autophagy, a process that helps clear damaged cells and may improve health outcomes. The researchers will conduct experiments using mice to see if disrupting this protein interaction can delay cognitive decline and other age-related issues associated with HIV. The findings could lead to new strategies for improving the quality of life for older adults with HIV.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and overall health in older adults living with HIV.
How similar studies have gone: Previous studies have shown promise in using autophagy modulation to improve health outcomes in aging populations, suggesting potential for success in this novel approach.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Rodriguez, Myosotys — Florida International University
- Study coordinator: Rodriguez, Myosotys
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.