Investigating how to predict epilepsy in newborns with seizures
Official title: NS-PEACE Neonatal Seizures -Predicting Epilepsy and Assessing Comparative Effectiveness
Funded at Weill Medical Coll of Cornell Univ · NIH-11074027 · Data updated 2026-11-12
This study is looking at the best medications to help newborns who have seizures, which can sometimes lead to bigger health issues later on, and it's for families with babies who might be experiencing these seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $677,582 |
| NIH project number | 5R01NS130113-03 |
| Project ID | NIH-11074027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns aged 0-28 days who have experienced acute symptomatic seizures.
✕Less likely to help
Patients who do not have neonatal seizures or are older than 28 days may not benefit from this research.
What this research studies
This research focuses on understanding neonatal seizures, which occur in about 1 in 1000 live births and can lead to serious conditions like epilepsy and cerebral palsy. The study aims to determine the most effective medications for treating these seizures and to explore how different treatments may influence the risk of developing further seizure disorders as the child grows. By analyzing data from 780 neonates across 18 medical centers, the researchers will compare the effectiveness of commonly used anti-seizure medications. This research is crucial for improving treatment strategies and outcomes for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options that reduce the risk of developing epilepsy in newborns who experience seizures.
How similar studies have gone: Previous research has shown promising results in the treatment of neonatal seizures, but this specific approach to comparing medication effectiveness is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Grinspan, Zachary Michael — Weill Medical Coll of Cornell Univ
- Study coordinator: Grinspan, Zachary Michael
Related research
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-
Investigating a new treatment for seizures using a specific inhibitor in mice
This study is looking at how a special treatment might help reduce seizures in mice with epilepsy, especially when the condition starts after injuries like strokes or head trauma, and it uses a method that could be easier and safer than current treatments.
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This study is looking for new ways to predict seizures and improve treatment for people with epilepsy by using smart technology to analyze mouse behaviors, which could help us better understand the condition and how it affects individuals.
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How mild traumatic brain injuries affect brain function and seizures in veterans with epilepsy
This study is looking at how mild traumatic brain injuries can affect brain function and lead to epilepsy in veterans, and it aims to find new ways to help improve their symptoms and overall quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.