Investigating how to modify a key enzyme involved in Alzheimer's disease
Official title: Molecular mechanisms of gamma-secretase modulation central to Alzheimer’s disease
Funded at Sloan-Kettering Inst Can Research · NIH-10984494 · Data updated 2026-11-12
This study is looking at how a specific enzyme related to Alzheimer's disease works, with the goal of finding new ways to lower harmful substances in the brain while keeping the enzyme functioning properly, which could help in developing better treatments for Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $723,560 |
| NIH project number | 5R01AG080684-03 |
| Project ID | NIH-10984494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia unrelated to β-amyloid production may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms of γ-secretase, an enzyme that plays a crucial role in the production of β-amyloid peptides linked to Alzheimer's disease. By exploring how this enzyme's activity can be modulated, the research aims to develop new therapeutic agents that can selectively reduce harmful β-amyloid without disrupting the enzyme's overall function. The study employs an interdisciplinary approach, utilizing novel reagents and techniques to gain insights into the enzyme's behavior in different cellular contexts. This could lead to innovative strategies for treating or preventing Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in targeting γ-secretase modulation, indicating potential for success in this approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Li, Yueming — Sloan-Kettering Inst Can Research
- Study coordinator: Li, Yueming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.