Investigating how to measure cognitive function in patients with immune thrombotic thrombocytopenic purpura (iTTP)
Official title: A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)
Funded at Duke University · NIH-10947615 · Data updated 2026-11-12
This study is looking to better understand how immune thrombotic thrombocytopenic purpura (iTTP) affects thinking and memory, so that patients can share their experiences and help improve treatments for their cognitive challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $456,348 |
| NIH project number | 1R21TR004694-01A1 |
| Project ID | NIH-10947615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with immune thrombotic thrombocytopenic purpura (iTTP) who experience cognitive function issues.
✕Less likely to help
Patients who do not have iTTP or those whose cognitive function is not significantly affected by the condition may not benefit from this research.
What this research studies
This research focuses on improving the assessment of cognitive function in patients with immune thrombotic thrombocytopenic purpura (iTTP), a rare blood disorder. It aims to develop and validate patient-reported outcome measures that accurately reflect the cognitive challenges faced by these patients. By conducting a comprehensive evaluation of cognitive function, the study seeks to align clinical trials with FDA recommendations for patient-focused drug development. This will ultimately help ensure that new therapies can be effectively evaluated for their impact on cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for patients with iTTP by ensuring that cognitive function improvements are accurately measured and reported.
How similar studies have gone: While there have been studies on cognitive function in other conditions, this specific approach to validating cognitive measures in iTTP is novel and has not been extensively tested.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Onwuemene, Oluwatoyosi Adefunke — Duke University
- Study coordinator: Onwuemene, Oluwatoyosi Adefunke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.