Investigating how to manipulate redox metabolism in living cells
Official title: Expanding the set of genetically encoded tools for compartment-specific manipulation of redox metabolism in living cells
Funded at Scintillon Institute for Photobiology · NIH-11115827 · Data updated 2026-11-12
This study is looking at how to better manage the flow of tiny particles called electrons in our cells, which is important for keeping us healthy, and it aims to find new ways to help people with conditions like cancer, diabetes, and neurodegeneration by understanding how to fix imbalances in our cell processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scintillon Institute for Photobiology NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $480,000 |
| NIH project number | 5R35GM142495-05 |
| Project ID | NIH-11115827 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions associated with redox metabolism imbalances, such as cancer, diabetes, or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to redox metabolism or those who do not have metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding and manipulating the flow of electrons in cellular processes, specifically through redox reactions that are crucial for maintaining cellular health. By developing genetically encoded tools, the researchers aim to selectively alter the concentrations of important cofactors like NADH and NADPH in living cells. This approach could help clarify the role of redox imbalances in various diseases, including cancer, diabetes, and neurodegeneration, and may lead to new therapeutic strategies. Patients may benefit from insights gained about how to restore balance in these critical metabolic pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to redox imbalances, improving patient outcomes.
How similar studies have gone: Other research has shown promise in manipulating redox metabolism, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
Scintillon Institute for Photobiology
San Diego, United States Active
Researchers
- Principal investigator: Cracan, Valentin — Scintillon Institute for Photobiology
- Study coordinator: Cracan, Valentin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.