Investigating how to improve treatment for chronic Helicobacter pylori infections
Understanding and manipulating chronic Helicobacter pylori to enhance treatment
This study is looking into why it's tough to treat long-lasting Helicobacter pylori infections with antibiotics and how stomach acid affects this, so we can find better ways to help people dealing with issues like ulcers and stomach cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10861753 on NIH RePORTER |
What this research studies
This research aims to understand why chronic Helicobacter pylori infections are difficult to treat with antibiotics. It focuses on the role of stomach acid in limiting antibiotic effectiveness and explores how proton pump inhibitors (PPIs) can alter the growth state of the bacteria. By studying the metabolism of H. pylori and the factors that promote its growth, the research seeks to enhance current treatment strategies for millions of people suffering from related diseases, such as ulcers and gastric cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic Helicobacter pylori infections who have not responded adequately to standard antibiotic treatments.
Not a fit: Patients who do not have a Helicobacter pylori infection or those who have already been successfully treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic Helicobacter pylori infections, reducing the incidence of ulcers and gastric cancer.
How similar studies have performed: Previous research has shown that understanding bacterial growth states can lead to improved treatment strategies, suggesting potential success for this approach.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Ottemann, Karen M — University of California Santa Cruz
- Study coordinator: Ottemann, Karen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.