Investigating how to improve heart cell production from stem cells
A Multi-Omics Approach to Discover Metabolic Critical Quality Attributes for Cardiomyocyte Biomanufacturing
This study is looking at how to grow heart cells from special stem cells in the lab, so we can better understand how they develop and eventually use them to help treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10435467 on NIH RePORTER |
What this research studies
This research focuses on enhancing the production of heart cells derived from human induced pluripotent stem cells (iPSCs). The team aims to identify key metabolic changes that occur as these cells mature into functional heart cells, which is crucial for their use in therapies for heart conditions. By employing advanced techniques to analyze metabolites and enzymes, the researchers will compare the maturation processes of these cells in the lab to those that occur naturally in the body. This approach will help develop better methods for producing mature heart cells that can be used in regenerative medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have heart conditions or are at risk for cardiac arrhythmias.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with heart diseases by providing more effective heart cells for transplantation or drug testing.
How similar studies have performed: Previous research has shown promise in using similar metabolic profiling approaches to enhance cell maturation, indicating potential for success in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Palecek, Sean P — University of Wisconsin-Madison
- Study coordinator: Palecek, Sean P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.