Investigating how to improve breathing during sleep in patients with obstructive sleep apnea
Project 1
This study is looking at ways to help people with obstructive sleep apnea breathe better during sleep by using special techniques to activate certain brain cells, which could lead to fewer interruptions in their sleep and better overall health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897851 on NIH RePORTER |
What this research studies
This research focuses on patients with obstructive sleep apnea (OSA), a condition where airway obstruction leads to disrupted sleep and cognitive impairment. The study aims to enhance brain circuits that help keep the airway open and reduce episodes of arousal that interrupt sleep. By using advanced techniques like optogenetics to activate specific neurons, researchers will measure changes in breathing patterns and muscle activity related to airway function. The goal is to find a way to improve ventilation and reduce the negative impacts of OSA on health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with obstructive sleep apnea who experience significant sleep disruption and cognitive issues.
Not a fit: Patients without obstructive sleep apnea or those whose sleep disturbances are caused by other conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve sleep quality and cognitive function for patients with obstructive sleep apnea.
How similar studies have performed: Previous research has shown promise in using optogenetic techniques to manipulate neural circuits, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Saper, Clifford B — Beth Israel Deaconess Medical Center
- Study coordinator: Saper, Clifford B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.