Investigating how to help human beta cells regenerate in diabetes
DREAM Complex Maintenance of Human Beta Cell Quiescence
This study is looking at how to help the pancreas grow more insulin-producing cells, which could be really helpful for people with Type 1 and Type 2 diabetes, by testing different proteins and treatments that might boost their growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11091424 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms that prevent human pancreatic beta cells from regenerating, which is crucial for treating Type 1 and Type 2 diabetes. The study explores the role of specific proteins and inhibitors that can promote the replication of these cells, aiming to enhance their proliferation rates. By combining different therapeutic agents, the researchers hope to overcome the barriers that limit beta cell growth and improve the overall function of the pancreas in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Type 1 or Type 2 diabetes.
Not a fit: Patients who do not have diabetes or those with other forms of pancreatic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore the function of insulin-producing beta cells, potentially reversing diabetes.
How similar studies have performed: Other research has shown promising results with similar approaches, particularly in the use of DYRK1A inhibitors to promote beta cell replication.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Stewart, Andrew F. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Stewart, Andrew F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.