Investigating how to create long-lasting immune memory in the lungs against influenza
Cellular and molecular programming of lung resident T cell memory
This study is looking at new vaccines that can boost your immune system in the lungs to help protect against the flu, aiming to find the best ways to help you recover faster and feel better if you do get sick.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11082210 on NIH RePORTER |
What this research studies
This research focuses on developing vaccines that enhance the immune response specifically in the lungs to provide long-lasting protection against influenza. It aims to understand the cellular and molecular mechanisms that support the generation and maintenance of lung-resident T cell memory, which is crucial for effective immunity. By studying animal models and human responses, the research seeks to identify optimal vaccination strategies that can lead to improved outcomes in fighting influenza infections. The ultimate goal is to create vaccines that not only reduce viral loads but also lead to quicker recovery and milder symptoms in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals at high risk for influenza complications, such as the elderly or those with chronic respiratory conditions.
Not a fit: Patients who are not at risk for influenza or those who have already developed strong immunity to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines that provide durable immunity and reduce the severity of infections.
How similar studies have performed: Previous research has shown promise in enhancing T cell memory responses in other contexts, suggesting potential for success in this novel approach to influenza vaccination.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kohlmeier, Jacob E — Emory University
- Study coordinator: Kohlmeier, Jacob E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.