Investigating how TNF receptor 2 affects immune cells in asthma
Role of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid Cells
This study is looking at how a protein called TNF affects certain immune cells that play a role in asthma and respiratory inflammation, with the goal of finding new ways to improve treatments for asthma and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11001185 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TNF receptor 2 in a specific type of immune cell known as Group 2 innate lymphoid cells (ILC2), which are involved in respiratory inflammation and allergic asthma. The researchers aim to explore how TNF, a protein found in high levels in the lungs of asthma patients, influences these immune cells and contributes to airway inflammation. By examining the signaling pathways and mechanisms involved, the study seeks to identify new therapeutic targets that could lead to better treatments for asthma and related airway diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with allergic asthma or other airway inflammatory diseases.
Not a fit: Patients with non-allergic asthma or those without significant airway inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for patients suffering from asthma and other respiratory inflammatory conditions.
How similar studies have performed: Previous research has shown promising results in targeting immune pathways in asthma, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Akbari, Omid — University of Southern California
- Study coordinator: Akbari, Omid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.