Investigating how TNF blockers affect benign prostatic hyperplasia and urinary symptoms in men.
Effects of TNF Blockade on Human BPH/LUTS
This study is looking at how a specific treatment can help older men with prostate enlargement and urinary issues by reducing inflammation, especially for those who haven't found relief with regular medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project ID | NIH-11163248 on NIH RePORTER |
What this research studies
This research explores the impact of TNF blockade on benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in aging men. It aims to understand how inflammation contributes to the severity of these conditions and the failure of standard treatments. The study will involve assessing the effects of TNF-antagonists, such as adalimumab, on prostate health and symptom relief. By analyzing patient responses, the research seeks to identify new therapeutic strategies for those who do not respond to current medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are aging men experiencing symptoms of benign prostatic hyperplasia and lower urinary tract symptoms, particularly those with inflammatory co-morbidities.
Not a fit: Patients who do not have benign prostatic hyperplasia or lower urinary tract symptoms are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for men suffering from BPH and LUTS, potentially reducing the need for surgical interventions.
How similar studies have performed: Previous research has shown promising results with TNF-antagonists in reducing BPH diagnoses among patients with autoimmune inflammatory diseases, indicating potential for success in this study.
Where this research is happening
Evanston, United States
- Endeavor Health Clinical Operations — Evanston, United States (Active)
Researchers
- Principal investigator: Hayward, Simon W — Endeavor Health Clinical Operations
- Study coordinator: Hayward, Simon W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.