Investigating how TNF blockers affect benign prostatic hyperplasia and urinary symptoms in men.
Official title: Effects of TNF Blockade on Human BPH/LUTS
Funded at Endeavor Health Clinical Operations · NIH-11163248 · Data updated 2026-11-12
This study is looking at how a specific treatment can help older men with prostate enlargement and urinary issues by reducing inflammation, especially for those who haven't found relief with regular medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $711,954 |
| NIH project number | 5R01DK135516-03 |
| Project ID | NIH-11163248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging men experiencing symptoms of benign prostatic hyperplasia and lower urinary tract symptoms, particularly those with inflammatory co-morbidities.
✕Less likely to help
Patients who do not have benign prostatic hyperplasia or lower urinary tract symptoms are unlikely to benefit from this research.
What this research studies
This research explores the impact of TNF blockade on benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in aging men. It aims to understand how inflammation contributes to the severity of these conditions and the failure of standard treatments. The study will involve assessing the effects of TNF-antagonists, such as adalimumab, on prostate health and symptom relief. By analyzing patient responses, the research seeks to identify new therapeutic strategies for those who do not respond to current medications.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for men suffering from BPH and LUTS, potentially reducing the need for surgical interventions.
How similar studies have gone: Previous research has shown promising results with TNF-antagonists in reducing BPH diagnoses among patients with autoimmune inflammatory diseases, indicating potential for success in this study.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Hayward, Simon W — Endeavor Health Clinical Operations
- Study coordinator: Hayward, Simon W
Related research
Other NIH-funded projects on the same topics.
-
Enhanced MRI to detect brain metastases
This project uses a new contrast MRI method to make very small brain metastases and leptomeningeal disease easier to see in adults with cancer.
-
Understanding how families’ circumstances affect a child’s language and thinking development
This project looks at how a child’s early environment and SES shapes language and cognitive development through biological and psychological pathways.
-
TNF blockers and enlarged prostate in aging men
A study explores whether blocking TNF can help reduce symptoms and enlargement of the prostate in men with BPH/LUTS.
-
Why menstrual pain becomes chronic pelvic pain
We will follow young women with menstrual pain, including those with bladder sensitivity, to learn who develops ongoing pelvic pain and which early signs predict it.
-
Fat-rich TREM2+ immune cells that may drive an enlarged prostate
This project looks at whether fat-filled immune cells called TREM2+ macrophages cause prostate enlargement and if targeting them could help men with BPH.
-
How cholesterol and tiny fat droplets affect brain cells in Alzheimer's
This project explores whether abnormal cholesterol and small fat droplets inside nerve cells harm people with Alzheimer's or those at higher genetic risk (for example, APOE4 carriers) and whether targeting these problems could protect the brain.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.