Investigating how TNF alpha affects recovery from liver injury caused by alcohol.
Official title: TNF alpha and Recovery from Alcoholic Liver Injury
Funded at Duke University · NIH-11041351 · Data updated 2026-11-12
This study is looking at how the liver heals after damage from alcohol and how certain proteins help liver cells grow back, with the goal of finding new ways to help people with serious alcohol-related liver problems recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 5, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $605,543 |
| NIH project number | 2R01AA010154-29A1 |
| Project ID | NIH-11041351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are adults over 21 years old who have experienced alcohol-induced liver injury or related conditions.
✕Less likely to help
Patients with liver injuries not related to alcohol consumption or those with other underlying liver diseases may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind alcohol-related liver diseases, particularly how the body repairs itself after alcohol-induced liver injury. The study examines the role of RNA binding proteins in regulating liver cell regeneration and the balance between fetal and adult liver cell programs. By analyzing how these processes are disrupted in patients with severe alcohol-related liver conditions, the research aims to identify potential therapeutic targets for improving liver recovery. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance liver recovery in individuals suffering from alcohol-related liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding liver regeneration mechanisms, but this specific approach focusing on RNA binding proteins in the context of alcohol-related liver injury is relatively novel.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Diehl, Anna Mae Elizabeth — Duke University
- Study coordinator: Diehl, Anna Mae Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.