Investigating how TMPRSS13 contributes to breast cancer progression
Tumor-promoting functions of TMPRSS13 in breast cancer progression
This study is looking at a protein called TMPRSS13 that is more common in breast cancer cells than in healthy ones, and it's using special mice without this protein to see how it affects tumor growth and spread, especially to the lungs, with the hope of finding new ways to treat breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10435484 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TMPRSS13, a protein that is found in higher levels in breast cancer cells compared to normal cells. By using a special mouse model that lacks TMPRSS13, researchers aim to uncover how this protein influences tumor growth and spread, particularly to the lungs. The study will involve various laboratory techniques to explore how TMPRSS13 affects cell survival and invasion, with the goal of identifying it as a potential new target for breast cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with aggressive forms of the disease.
Not a fit: Patients with non-malignant breast conditions or those without breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for breast cancer patients by targeting TMPRSS13.
How similar studies have performed: Previous research has shown promising results in targeting similar proteins in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: List, Karin — Wayne State University
- Study coordinator: List, Karin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.