Investigating how TMEM106B affects frontotemporal dementia
Official title: The Role of TMEM106B in FTLD-TDP Pathogenesis
Funded at Mayo Clinic Jacksonville · NIH-11128325 · Data updated 2026-11-12
This study is looking at how a protein called TMEM106B might affect the risk of developing frontotemporal dementia (FTD), which is a type of Alzheimer's disease, to help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | December 6, 2023 |
| Project end | June 5, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,174 |
| NIH project number | 5F30AG085984-02 |
| Project ID | NIH-11128325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of frontotemporal dementia or those diagnosed with related neurodegenerative conditions.
✕Less likely to help
Patients with other forms of dementia that do not involve TMEM106B or frontotemporal degeneration may not benefit from this research.
What this research studies
This research focuses on understanding the role of the TMEM106B protein in the development of frontotemporal dementia (FTD), a type of Alzheimer's disease. Researchers will examine specific genetic variations (SNPs) in TMEM106B that may influence the risk of developing FTD. By studying how these genetic changes affect the protein's function and its role in brain health, the research aims to uncover potential mechanisms behind the disease. This could lead to new insights into how FTD progresses and how it might be treated.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for frontotemporal dementia.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors associated with neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Marks, Jordan David — Mayo Clinic Jacksonville
- Study coordinator: Marks, Jordan David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.