Investigating how TMEM106b affects brain aging and tau-related diseases
TMEM106b as a lysosomal adaptor to influence brain aging and tau pathogenesis
This study is looking at a protein called TMEM106b to see how it affects brain health as we age, especially in conditions like Alzheimer's, and it aims to find ways to help improve thinking and memory in older adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11051227 on NIH RePORTER |
What this research studies
This research explores the role of TMEM106b, a protein associated with brain health, particularly in aging and neurodegenerative diseases like Alzheimer's. The study aims to understand how TMEM106b influences lysosomal function, which is crucial for maintaining brain cell health. By examining the effects of different TMEM106b levels on brain cells, the research seeks to identify potential therapeutic targets that could improve cognitive health in older adults. Patients may be involved in assessments that help determine the relationship between TMEM106b and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults aged 65 and older, particularly those experiencing cognitive decline or at risk for neurodegenerative diseases.
Not a fit: Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of TMEM106b in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Jankowsky, Joanna L — Baylor College of Medicine
- Study coordinator: Jankowsky, Joanna L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.