Investigating how TLR4 and Lyn interaction affects brain inflammation after a hemorrhagic stroke
Official title: Modulation of the TLR4-Lyn interaction in SAH
Funded at Rowan University · NIH-10844778 · Data updated 2026-11-12
This study is looking at how a certain receptor in the brain might cause inflammation after a bleeding stroke, and it hopes to find ways to reduce that inflammation safely, which could help people recover better from this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University NIH-funded |
| Lab location | 1 site (Glassboro, United States) |
| Project start | June 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $361,788 |
| NIH project number | 7R01NS109174-06 |
| Project ID | NIH-10844778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered a hemorrhagic stroke, particularly those with aneurysmal subarachnoid hemorrhage.
✕Less likely to help
Patients who have not experienced a hemorrhagic stroke or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific receptor, TLR4, in causing inflammation in the brain following a hemorrhagic stroke, which occurs when there is bleeding in the brain. The study uses animal models to explore how modulating the interaction between TLR4 and Lyn kinase can potentially reduce this inflammation without causing harmful immunosuppression. By examining the cellular responses involved, the research aims to identify new therapeutic strategies that could improve outcomes for patients suffering from this serious condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain inflammation and improve recovery outcomes for patients who have experienced a hemorrhagic stroke.
How similar studies have gone: While the approach of modulating TLR4 pathways is relatively novel, previous studies have shown promise in targeting inflammation in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
Rowan University
Glassboro, United States Active
Researchers
- Principal investigator: Hanafy, Khalid a. — Rowan University
- Study coordinator: Hanafy, Khalid a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.