Investigating how tiny structures in the brain affect neurodevelopmental disorders in children.
Synaptic nanostructure and dysfunction in neurodevelopmental disorders
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10991715
This study is looking at how tiny structures in the brain that help nerve cells communicate might be linked to conditions like autism and schizophrenia, with the goal of finding new ways to help kids who are affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10991715 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of synaptic nanostructures in neurodevelopmental disorders like autism spectrum disorder (ASD) and schizophrenia, which affect over 3% of children globally. Researchers will explore how genetic variations in synaptic proteins impact the way information is transmitted between neurons in the brain. Using advanced techniques such as cryogenic electron tomography, biochemical assays, and cell imaging, the study aims to create a detailed map of these synaptic structures and their functions. By uncovering the mechanisms behind these disorders, the research seeks to pave the way for new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with neurodevelopmental disorders, particularly autism spectrum disorder.
Not a fit: Patients with neurodevelopmental disorders outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for neurodevelopmental disorders in children.
How similar studies have performed: Previous research has shown promising results in understanding synaptic dysfunction in neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, QIANGJUN — VANDERBILT UNIVERSITY
- Study coordinator: ZHOU, QIANGJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder