Investigating how tiny RNA molecules affect metabolic risks in children
Role of miRNAs in the transmission of metabolic risks
This study is looking at how tiny molecules called microRNAs might affect childhood obesity and how things like a dad's exercise habits can influence his children's health, using fruit flies to help us understand these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-10807976 on NIH RePORTER |
What this research studies
This research explores the role of microRNAs (miRNAs) in the development of metabolic disorders, particularly focusing on childhood obesity. It examines how environmental factors and ancestral exposures can influence the metabolic health of offspring, using fruit flies as a model organism due to their genetic simplicity. The study aims to understand how paternal exercise can alter mitochondrial efficiency in offspring and how these changes may be transmitted through sperm cells. By analyzing the genetic and biochemical changes associated with these processes, the research seeks to uncover mechanisms that could lead to better prevention strategies for obesity and related metabolic conditions in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who may be at risk for obesity or metabolic disorders due to familial or environmental factors.
Not a fit: Patients who are not children or do not have a family history of metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing childhood obesity and its associated metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and environmental factors contributing to obesity, making this approach a continuation of established findings.
Where this research is happening
Baton Rouge, United States
- Louisiana State Univ A&m Col Baton Rouge — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Murashov, Alexander K. — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Murashov, Alexander K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.