Investigating how tiny particles affect bladder toxicity in prostate cancer patients after radiation treatment
Clinical and pre-clinical investigation of extracellular vesicles as a mechanism of toxicity in the bladder of prostate cancer patients treated with radiotherapy
This study is looking at tiny particles in the body called extracellular vesicles to see if they can help predict bladder problems in prostate cancer patients who have had radiation treatment, with the goal of finding better ways to manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11067761 on NIH RePORTER |
What this research studies
This research focuses on understanding how extracellular vesicles (EVs) contribute to radiation cystitis, a condition affecting about 15% of prostate cancer patients who have undergone radiotherapy. The study aims to identify these vesicles as potential biomarkers for predicting bladder toxicity and to explore their role in the disease's development. By analyzing preserved samples from previous studies, researchers hope to establish a link between EV levels and the onset of bladder complications, which could lead to better management strategies for affected patients. The approach combines laboratory analysis with insights from previous genomic studies to enhance patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are prostate cancer patients who have received radiotherapy and are experiencing or at risk of developing bladder complications.
Not a fit: Patients who have not undergone radiotherapy or those with bladder issues unrelated to cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for bladder toxicity in prostate cancer survivors.
How similar studies have performed: While there has been limited research on EVs in this context, preliminary findings suggest a promising link between EV levels and bladder toxicity, indicating potential for further exploration.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lee, Yi-Fen — University of Rochester
- Study coordinator: Lee, Yi-Fen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.