Investigating how tiny forces from immune cells affect cancer treatment
Measuring and Programming Piconewton Receptor Forces for Synthetic Mechanobiology
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11020815
This study is looking at how immune cells called T cells move and push against cancer cells and nearby tissues, using special tools to see these tiny forces, with the hope of finding better ways to help your body fight cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11020815 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanical forces that immune cells, particularly T cells, exert at a microscopic level. By developing innovative technologies to visualize these forces, the study aims to explore how T cells interact with cancer cells and the surrounding tissue. The researchers will measure these forces in materials that mimic the body's tissues, which could lead to new insights into how to enhance the effectiveness of cancer immunotherapy. Patients may benefit from improved treatments that better harness the body's immune response against cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing treatment for cancer who may benefit from enhanced immunotherapy approaches.
Not a fit: Patients with non-cancerous conditions or those not receiving immunotherapy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer immunotherapies by optimizing how immune cells interact with tumors.
How similar studies have performed: Previous research has shown promise in understanding cellular forces in cancer treatment, indicating that this approach could lead to significant advancements.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROCKMAN, JOSHUA MARK — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BROCKMAN, JOSHUA MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy, anticancer immunotherapy