Investigating how tight junctions in cells control ion and water movement
Defining single-channel paracellular (tight junction) conductances using nanotechnology
['FUNDING_R21'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10771236
This study is looking at how certain proteins help keep the barriers in our body’s cells working properly, which could lead to new ways to treat conditions like colitis by fixing problems with these barriers.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10771236 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of tight junctions in epithelial and endothelial cells, which are crucial for maintaining barriers in the body. By using advanced nanotechnology, the study aims to explore how specific proteins called claudins form channels that regulate the movement of ions and water between cells. The research will involve both laboratory experiments and potential applications in treating conditions like colitis, where these channels may be dysfunctional. Patients may benefit from insights gained about how to manipulate these channels for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions like colitis or other disorders linked to tight junction dysfunction.
Not a fit: Patients with conditions unrelated to epithelial or endothelial barrier function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to dysfunctional tight junctions, such as inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding tight junctions and their role in diseases, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TURNER, JERROLD R. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: TURNER, JERROLD R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.