Investigating how thyroid hormones help muscles heal after injury
Official title: Thyroid hormone signaling in skeletal muscle regeneration
Funded at VA Greater Los Angeles Healthcare System · NIH-10923254 · Data updated 2026-11-12
This study is looking at how thyroid hormones help muscles heal after injuries, especially for people who have had serious injuries or muscle diseases, to find new ways to boost muscle recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006245-01A2 |
| Project ID | NIH-10923254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced significant muscle injuries, such as combat veterans or individuals with degenerative muscle diseases.
✕Less likely to help
Patients with minor muscle injuries or those without significant muscle loss may not benefit from this research.
What this research studies
This research focuses on understanding the role of thyroid hormones in the regeneration of skeletal muscle after injuries, particularly in individuals who have experienced severe injuries or degenerative diseases. The study will explore how thyroid hormones influence muscle stem cells (MuSCs), which are crucial for muscle repair. Using advanced in vitro and in vivo models, researchers will investigate the molecular mechanisms behind thyroid hormone signaling and its effects on MuSC proliferation and differentiation. The ultimate goal is to identify potential therapeutic targets that could enhance muscle regeneration.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle healing and recovery for patients with severe injuries or muscle degenerative conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of thyroid hormones in muscle regeneration, suggesting that this approach could lead to meaningful advancements.
Where this research is happening
-
VA Greater Los Angeles Healthcare System
Los Angeles, United States Active
Researchers
- Principal investigator: Milanesi, Anna — VA Greater Los Angeles Healthcare System
- Study coordinator: Milanesi, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.