Investigating how thrombospondin1 affects heart muscle size changes
Official title: Thrombospondin1-regulated atrophy in the heart
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10983347 · Data updated 2026-11-12
This study is looking at how a protein called thrombospondin1 affects the size of heart muscle cells, especially when the heart is under stress or not getting enough nutrients, to help find new ways to improve heart health for people dealing with muscle shrinkage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $547,141 |
| NIH project number | 5R01HL162595-03 |
| Project ID | NIH-10983347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing heart muscle atrophy or related cardiac conditions.
✕Less likely to help
Patients with stable heart conditions who do not exhibit signs of muscle atrophy may not benefit from this research.
What this research studies
This research explores the role of thrombospondin1 in regulating the size of heart muscle cells, particularly during conditions of stress or nutrient deficiency. It examines how these cells can shrink, a process known as atrophy, and how this is linked to heart disease and overall heart health. By understanding the molecular pathways involved, the research aims to identify potential therapeutic targets for improving heart function in patients experiencing muscle atrophy.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help maintain or restore heart muscle size and function in patients with heart disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of molecular pathways in muscle atrophy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Molkentin, Jeffery D — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Molkentin, Jeffery D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.