Investigating how therapeutic vaccines can help control HIV-1 infection
Multi-Omics Correlates of Therapeutic Vaccine Efficacy
This study is looking at ways to boost the immune system's ability to fight HIV-1, aiming to help people control the virus without needing daily medication, and it will use monkeys to learn more about how different vaccines can improve immune responses.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11084521 on NIH RePORTER |
What this research studies
This research aims to enhance the immune response against HIV-1 through therapeutic vaccination, striving for a functional cure that allows patients to maintain viral control without antiretroviral therapy (ART). The study will analyze immune responses in SIV/SHIV-infected rhesus macaques to identify immune signatures associated with successful viral control. By employing advanced multi-omics techniques, researchers will explore how different immunization strategies affect immune responses in lymphoid tissues, which are critical for managing the virus. The findings could lead to improved vaccine designs for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in innovative treatment options and have not achieved viral suppression with standard ART.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS with significant immune compromise may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic vaccines that help patients achieve long-term control of HIV-1 without the need for continuous medication.
How similar studies have performed: Previous studies in non-human primates have shown promising results with therapeutic vaccines, indicating potential for success in human applications.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Juelg, Boris Dominik — Beth Israel Deaconess Medical Center
- Study coordinator: Juelg, Boris Dominik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.