Investigating how the ZFX protein regulates gene expression in different cell types
How does the ubiquitously expressed ZFX mediate cell type-specific transcriptional regulation
This study is looking at a protein called ZFX and how it helps control the activity of genes in different types of human cells, which could lead to better understanding and treatments for conditions like cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10897940 on NIH RePORTER |
What this research studies
This research focuses on the ZFX family of transcription factors, particularly ZFX, and how it influences gene expression in various human cell types. Using advanced techniques like CRISPR and ChIP-seq, the study aims to uncover the mechanisms by which ZFX binds to DNA and interacts with other proteins to regulate specific genes in different cells. By understanding these interactions, the research seeks to clarify how ZFX contributes to cellular functions and potentially impacts conditions like cancer. Patients may benefit from insights gained into gene regulation that could inform future therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cancers or other conditions related to gene expression dysregulation.
Not a fit: Patients with conditions unrelated to gene regulation or those not expressing ZFX may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene regulation in diseases such as cancer.
How similar studies have performed: Other research has shown success in understanding transcription factors and their roles in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsu, Emily — University of Southern California
- Study coordinator: Hsu, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.