Investigating how the upper esophagus helps with swallowing and airway protection
Deglutitive and airway protective functions of proximal/ striated muscle esophagus in health and disease
This study is looking at how the muscles in the upper part of the esophagus work when we swallow, especially in healthy people and those who might have trouble swallowing, like older adults or stroke survivors, to help find better ways to keep them safe from choking.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11099723 on NIH RePORTER |
What this research studies
This research focuses on understanding the motor functions of the proximal or striated esophagus, which plays a crucial role in swallowing and protecting the airway from aspiration. The study aims to characterize how these functions are affected by biomechanics during swallowing, particularly in healthy individuals and patients. By examining the esophagus's response to different swallowing conditions, the research seeks to uncover important relationships that could inform better clinical practices. The findings may lead to improved diagnostic and therapeutic strategies for individuals at risk of aspiration, especially in older adults or those recovering from strokes.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals who have experienced a stroke, particularly those with swallowing difficulties.
Not a fit: Patients without swallowing difficulties or those who do not have conditions affecting esophageal function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management of aspiration pneumonia and related complications in vulnerable populations.
How similar studies have performed: Previous research has shown promising results in understanding esophageal functions, but this specific investigation into the proximal esophagus is relatively novel.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Shaker, Reza None — Medical College of Wisconsin
- Study coordinator: Shaker, Reza None
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.