Investigating how the tumor microenvironment affects therapy response using advanced imaging techniques
High dimensional digital pathology to investigate the tumor micro environment and its impact on response to therapy
This study is looking at how the area around tumors affects how well cancer treatments work, using skin samples to find important markers that could help create more personalized and effective therapies for patients with melanoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911319 on NIH RePORTER |
What this research studies
This research focuses on understanding the tumor microenvironment and its influence on how patients respond to cancer therapies. Using a method called tissue-based cyclic immunofluorescence (t-CyCIF), researchers will analyze human and mouse skin samples to identify and validate biomarkers related to skin development, inflammation, and melanoma progression. The study aims to create a detailed atlas of disease pathology by processing high-resolution images and providing quantitative analyses of cell and tissue interactions. This approach could lead to better-targeted treatments for patients based on their unique tumor environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma or other skin-related cancers who are undergoing therapy.
Not a fit: Patients with non-cancerous skin conditions or those not receiving any form of therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer therapies by improving our understanding of tumor biology.
How similar studies have performed: Previous research using similar imaging techniques has shown promise in enhancing our understanding of tumor biology and improving treatment outcomes.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Maliga, Zoltan — Harvard Medical School
- Study coordinator: Maliga, Zoltan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.