Investigating how the tumor environment influences the spread of high-risk prostate cancer
Project 1: Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer
This study is looking at how the area around prostate tumors affects the spread of high-risk prostate cancer, using advanced imaging to help find better treatment options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10899411 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the tumor microenvironment in the spread of high-risk prostate cancer. It involves analyzing pre-treatment samples from patients undergoing different therapies, including surgery and neoadjuvant treatments. By using advanced imaging techniques like PSMA PET/MRI scans, researchers will create 3D models of the prostate to study how specific genomic alterations interact with various cell types in the tumor environment. This approach aims to uncover mechanisms that lead to cancer metastasis, which could inform more effective treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with high-risk prostate cancer who are scheduled for surgery or neoadjuvant therapy.
Not a fit: Patients with low-risk prostate cancer or those not undergoing surgical or neoadjuvant treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with high-risk prostate cancer.
How similar studies have performed: Previous research has shown promising results in understanding the tumor microenvironment's role in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Lang, Joshua Michael — University of Wisconsin-Madison
- Study coordinator: Lang, Joshua Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.