Investigating how the thalamus affects seizures and memory
Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11071177
This study is looking at how certain parts of the brain called the thalamus might influence the spread of seizures in people with epilepsy and how this affects their memory, so if you have drug-resistant epilepsy, you could help us learn more by participating in some brain stimulation tests.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11071177 on ClinicalTrials.gov |
What this research studies
This research explores the role of the thalamus, specifically the anterior nucleus and pulvinar, in the propagation of temporal lobe seizures and their impact on memory. By examining the connections between these thalamic regions and other brain structures, the study aims to understand how seizures spread and how neuromodulation techniques can affect memory processing. Patients with drug-resistant epilepsy will undergo direct electrical stimulation of the thalamus while their brain activity is monitored, providing insights into the relationship between seizure activity and memory function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with drug-resistant epilepsy who are experiencing memory issues related to their condition.
Not a fit: Patients with well-controlled epilepsy or those without memory impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with drug-resistant epilepsy, potentially reducing seizures and minimizing memory impairments.
How similar studies have performed: Previous research has shown promise in using neuromodulation techniques for epilepsy treatment, but this specific approach focusing on the thalamus is relatively novel.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARVIZI, JOSEF — STANFORD UNIVERSITY
- Study coordinator: PARVIZI, JOSEF
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.