Investigating how the surrounding tissue affects ovarian cancer spread
Role of the microenvironment in ovarian cancer metastasis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10701874
This study is looking at how a protein called DDR2 helps ovarian cancer spread and is testing new drugs that could block this protein, with the hope of finding better treatments to help patients live longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10701874 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the microenvironment around ovarian cancer cells contributes to their ability to spread within the body. It specifically examines a protein called Discoidin Domain Receptor 2 (DDR2), which is found in high levels in many advanced ovarian tumors. By using advanced techniques, the research aims to test new drugs that inhibit DDR2, potentially preventing the cancer from metastasizing. Patients may benefit from this research as it seeks to develop new treatment strategies that could improve survival rates for those with ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with advanced-stage ovarian cancer, particularly those whose tumors express high levels of DDR2.
Not a fit: Patients with early-stage ovarian cancer or those whose tumors do not express DDR2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the spread of ovarian cancer and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting receptor tyrosine kinases in cancer treatment, indicating potential for success in this area.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUH, KATHERINE CYNTHIA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FUH, KATHERINE CYNTHIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer