Investigating how the strength of antigen binding affects CAR T cell activity
The role of antigen binding strength in CAR T cell activity
This study is looking at ways to make CAR T cell therapy better for kids with tough-to-treat solid tumors by figuring out how the connection between CAR T cells and cancer cells affects how well the treatment works.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10867429 on NIH RePORTER |
What this research studies
This research focuses on improving CAR T cell therapy, particularly for children with relapsed or refractory solid tumors. It examines how the strength of the binding between CAR T cells and their target antigens influences the effectiveness of these cells in attacking cancer. By understanding the balance between cytotoxicity and T cell survival, the study aims to enhance the potency of CAR T cells, potentially leading to better treatment outcomes. The research involves laboratory experiments to analyze cellular signaling pathways and their effects on T cell function.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have relapsed or refractory solid tumors.
Not a fit: Patients with non-solid tumors or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies for children with difficult-to-treat solid tumors.
How similar studies have performed: Previous research has shown promise in enhancing CAR T cell efficacy through modifications, suggesting potential for success in this approach.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Richman, Sarah Ann — Children's Hospital of Los Angeles
- Study coordinator: Richman, Sarah Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.