Investigating how the sodium pump functions in health and disease
The NKA Interactome in Health and Disease
['FUNDING_R01'] · LOYOLA UNIVERSITY CHICAGO · NIH-11061365
This study is looking at a special enzyme that helps keep our cells working properly, and it's trying to find out how certain proteins affect this enzyme's function, especially in conditions like Alzheimer's and heart disease, to help improve treatments for these illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-11061365 on ClinicalTrials.gov |
What this research studies
This research focuses on the Na/K-ATPase (NKA), an enzyme crucial for transporting ions across cell membranes, which plays a significant role in maintaining cell function and signaling. The project aims to understand how this enzyme is regulated by specific proteins called FXYDs and how these interactions can change under different physiological conditions. By using advanced spectroscopic techniques, the researchers will explore the structure and stability of NKA complexes and how these may be disrupted in diseases like Alzheimer's and cardiac conditions. The findings could lead to insights into how to better manage or treat these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, cardiac diseases, or other conditions related to sodium handling.
Not a fit: Patients with conditions unrelated to sodium transport or those not diagnosed with the target diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing diseases like Alzheimer's and heart failure by targeting the sodium pump's regulation.
How similar studies have performed: Previous research has shown promising results in understanding the role of ion transporters in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBIA, SETH L — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: ROBIA, SETH L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease