Investigating how the Smyd1 protein affects heart function
The methyltransferase Smyd1 regulates cardiac physiology
This study is looking at a protein called Smyd1 in heart cells to see how it affects heart health, especially for people with coronary artery disease, and hopes to find new ways to help improve heart function and metabolism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10880694 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Smyd1 protein in heart muscle cells and its impact on cardiac health. By using advanced techniques like CRISPR and studying specific mouse models, researchers aim to uncover how changes in Smyd1 expression can lead to heart failure. The study seeks to identify potential therapeutic targets that could improve heart metabolism and function, particularly in patients with coronary artery disease. If successful, this research could pave the way for new treatments that specifically target heart muscle cells to enhance their performance.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with coronary artery disease or those at risk of developing heart failure.
Not a fit: Patients with non-cardiac related conditions or those who do not have coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of heart failure in patients with coronary artery disease.
How similar studies have performed: Previous research has shown promise in targeting epigenetic regulators for cardiac health, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Franklin, Sarah — University of Utah
- Study coordinator: Franklin, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.