Investigating how the SMAD3 gene affects brain activity related to memory.
The role of SMAD3 in gene networks underlying human brain activity
['FUNDING_FELLOWSHIP'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11052450
This study is looking at how a gene called SMAD3 affects brain activity related to memory in people with epilepsy, and it hopes to help us understand more about memory problems in conditions like Alzheimer's.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11052450 on ClinicalTrials.gov |
What this research studies
This research explores the role of the SMAD3 gene in regulating brain activity associated with memory, particularly in patients with epilepsy. By analyzing gene expression data alongside brain oscillation patterns, the study aims to uncover how SMAD3 influences cognitive processes. The researchers are using advanced techniques to identify the connections between SMAD3 and other genes that may impact memory and cognitive function. This could lead to a better understanding of the molecular mechanisms underlying cognitive diseases like Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with epilepsy who are experiencing cognitive dysfunction or memory issues.
Not a fit: Patients without cognitive impairments or those not diagnosed with epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for improving memory and cognitive function in patients with neuropsychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding gene networks related to brain activity, suggesting that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOORE, HALEY D — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: MOORE, HALEY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease