Investigating how the proteasome, a protein degradation machine, is assembled and regulated in cells.
Understanding eukaryotic proteasome assembly regulation
This study is looking at how a key part of our cells, called the proteasome, works to break down damaged proteins, which could help us understand its role in diseases like Alzheimer's and find new ways to treat them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11033367 on NIH RePORTER |
What this research studies
This research focuses on understanding the assembly and regulation of the proteasome, a crucial cellular machine responsible for degrading damaged or unneeded proteins. By using mathematical modeling and experimental analyses, the study aims to uncover the mechanisms that control the expression of proteasome subunits, their assembly with chaperones, and the modifications that occur after translation. The findings could provide insights into how proteasome function is altered in diseases like Alzheimer's, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with conditions unrelated to proteasome function or those not diagnosed with neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases characterized by proteasome dysfunction, such as Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding proteasome dynamics can lead to significant advancements in treating diseases associated with protein degradation dysfunction.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lagunes, Leonila — University of California Los Angeles
- Study coordinator: Lagunes, Leonila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.