Investigating how the proteasome, a protein degradation machine, is assembled and regulated in cells.
Official title: Understanding eukaryotic proteasome assembly regulation
Funded at University of California Los Angeles · NIH-11033367 · Data updated 2026-11-12
This study is looking at how a key part of our cells, called the proteasome, works to break down damaged proteins, which could help us understand its role in diseases like Alzheimer's and find new ways to treat them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $100,620 |
| NIH project number | 1K99GM157504-01 |
| Project ID | NIH-11033367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with conditions unrelated to proteasome function or those not diagnosed with neurodegenerative diseases may not benefit from this research.
What this research studies
This research focuses on understanding the assembly and regulation of the proteasome, a crucial cellular machine responsible for degrading damaged or unneeded proteins. By using mathematical modeling and experimental analyses, the study aims to uncover the mechanisms that control the expression of proteasome subunits, their assembly with chaperones, and the modifications that occur after translation. The findings could provide insights into how proteasome function is altered in diseases like Alzheimer's, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases characterized by proteasome dysfunction, such as Alzheimer's disease.
How similar studies have gone: Previous research has shown that understanding proteasome dynamics can lead to significant advancements in treating diseases associated with protein degradation dysfunction.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Lagunes, Leonila — University of California Los Angeles
- Study coordinator: Lagunes, Leonila
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.