Investigating how the nose connects to the brain and nervous system
Official title: Functional MRI of the human nose: an unprecedented investigational window into the nervous system
Funded at University of Minnesota · NIH-11139905 · Data updated 2026-11-12
This study is looking at how the nose connects to the brain to better understand diseases like Alzheimer's and Parkinson's, and it involves non-invasive imaging to help find new ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $423,500 |
| NIH project number | 1R21DC022092-01A1 |
| Project ID | NIH-11139905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals experiencing early symptoms of neurodegenerative diseases, particularly those related to olfactory dysfunction.
✕Less likely to help
Patients with established neurodegenerative diseases who are not experiencing olfactory or autonomic symptoms may not benefit from this research.
What this research studies
This research explores the functional connections between the nose and the central nervous system, particularly in relation to neurodegenerative diseases like Alzheimer's and Parkinson's. By using advanced imaging techniques, the study aims to overcome challenges in detecting functional signals in the nose, which is crucial for understanding olfactory and autonomic functions. Patients may undergo non-invasive imaging to help identify mechanisms of disease and potential therapeutic interventions. The research seeks to establish the nose as a vital investigational target for neurological health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the early detection and treatment of neurodegenerative diseases.
How similar studies have gone: While the approach of using advanced imaging techniques for the nose is innovative, similar research has shown promise in understanding the connections between sensory organs and the nervous system.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mangia, Silvia — University of Minnesota
- Study coordinator: Mangia, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.