Investigating how the nervous system influences immune cell movement during inflammation
The role of neuro-immune synapse in macrophage migration
This study is looking at how a special receptor in our nervous system can help control inflammation by changing the way certain immune cells move, which could be helpful for people with conditions like arthritis and heart disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Tennessee State University NIH-funded |
| Lab location | 1 site (Johnson City, United States) |
| Project ID | NIH-10359594 on NIH RePORTER |
What this research studies
This research explores the role of the autonomic nervous system in regulating inflammation, particularly focusing on how a specific receptor, the α7 nicotinic acetylcholine receptor (α7nAChR), affects the movement of immune cells called macrophages. By using both animal models and laboratory tests, the researchers aim to understand how activating this receptor can change macrophage behavior and potentially reduce inflammation in conditions like arthritis and atherosclerosis. The study will involve examining the mechanisms behind macrophage migration and adhesion, which are crucial for the body's response to inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from inflammatory conditions such as arthritis, diabetes, or atherosclerosis.
Not a fit: Patients with non-inflammatory conditions or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness the body's nervous system to control inflammation and improve outcomes for patients with inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of the autonomic nervous system in inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
Johnson City, United States
- East Tennessee State University — Johnson City, United States (Active)
Researchers
- Principal investigator: Yakubenko, Valentin P — East Tennessee State University
- Study coordinator: Yakubenko, Valentin P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.