Investigating how the mouse inner ear regenerates cells after injury
Single cell analysis of mitotic regeneration in the mouse vestibular system
['FUNDING_CAREER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10864809
This study is exploring how baby mice can heal their inner ear after injury, especially how they can regrow important cells for hearing and balance, which could help us find new treatments for people with hearing loss or balance issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10864809 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the inner ear of neonatal mice can regenerate cells after injury, specifically looking at the mechanisms that allow for the recovery of hair cells essential for hearing and balance. By analyzing single cells in the vestibular system, the study aims to uncover the timing and processes involved in cell regeneration, particularly how certain signaling pathways, like the Wnt pathway, influence cell fate decisions. This could provide insights into potential therapies for hearing loss and balance disorders in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals experiencing sensorineural hearing loss or vestibular dysfunction.
Not a fit: Patients with hearing loss due to non-sensorineural causes or those who do not have vestibular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help regenerate hair cells in humans, potentially restoring hearing and balance.
How similar studies have performed: Other research has shown promising results in understanding cell regeneration in different systems, but this specific approach in the inner ear is relatively novel.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAN, TAHA A — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: JAN, TAHA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.