Investigating how the microbiome affects cervical cancer in women with HIV
The role of the microbiome in HPV-associated cervical cancer in women with HIV
This study is looking at how the bacteria in the cervix might affect the risk of cervical cancer in women with HIV, especially in places with fewer resources, to help find better ways to detect and treat the disease early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10835875 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between the microbiome and cervical cancer in women living with HIV, particularly in low and middle-income countries. It aims to improve early detection and treatment strategies for cervical cancer by identifying better predictors of disease progression and recurrence. The study will analyze the local cervical microbiome to determine its role in the development of precancerous lesions and invasive cervical cancer. By identifying specific bacterial profiles associated with higher risks, the research seeks to enhance screening and treatment protocols for HPV-positive women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women living with HIV who are HPV-positive and at risk for cervical cancer.
Not a fit: Patients who are not infected with HIV or who do not have HPV-related cervical issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate screening methods and targeted treatments for cervical cancer, ultimately reducing morbidity and mortality in affected populations.
How similar studies have performed: Preliminary evidence from other studies suggests that understanding the microbiome's role in cervical cancer progression could lead to significant advancements in treatment strategies.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Uhlemann, Anne-Catrin — Columbia University Health Sciences
- Study coordinator: Uhlemann, Anne-Catrin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.