Investigating how the LRRC57 gene affects brain function and behavior.
Official title: LRRC57 modulates neurotrophic growth factor signaling in synaptic function and behavior
Funded at St. Jude Children's Research Hospital · NIH-10952389 · Data updated 2026-11-12
This study is looking at a gene called LRRC57 to see how it affects brain growth and function, which could help us find new ways to treat bipolar disorder and similar mental health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $500,500 |
| NIH project number | 1R21MH138869-01 |
| Project ID | NIH-10952389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with bipolar disorder or those experiencing severe mood swings.
✕Less likely to help
Patients with neuropsychiatric conditions unrelated to bipolar disorder may not benefit from this research.
What this research studies
This research focuses on the LRRC57 gene, which has been linked to bipolar disorder, a condition that causes extreme mood swings. The study aims to understand how LRRC57 influences neurotrophic growth factors that are crucial for brain development and function. Using genetically modified mice, researchers will explore the role of LRRC57 in neurons and its impact on synaptic plasticity and cognition. By examining these mechanisms, the research seeks to uncover potential biological targets for treating bipolar disorder and related neuropsychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bipolar disorder and improve the understanding of neuropsychiatric diseases.
How similar studies have gone: While the specific role of LRRC57 is novel, similar research on neurotrophic factors has shown promise in understanding and treating mood disorders.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Zakharenko, Stanislav S — St. Jude Children's Research Hospital
- Study coordinator: Zakharenko, Stanislav S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.