Investigating how the loss of DNMT3A affects cell competition in developmental disorders.
Official title: Determining the effect of DNMT3A loss on the competitive fitness of mutant cells in somatic mosaicism
Funded at Baylor College of Medicine · NIH-10982465 · Data updated 2026-11-12
This study is looking at how changes in the DNMT3A gene affect the growth of tissues in people with Tatton-Brown-Rahman Syndrome, helping us understand how different types of cells work together and how this impacts health and development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 20, 2022 |
| Project end | December 19, 2026 |
| Funding year | 2025 |
| Award (this year) | $55,037 |
| NIH project number | 5F30HD111129-03 |
| Project ID | NIH-10982465 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Tatton-Brown-Rahman Syndrome or those exhibiting symptoms related to DNMT3A mutations.
✕Less likely to help
Patients without any genetic mutations in DNMT3A or those not diagnosed with TBRS may not benefit from this research.
What this research studies
This research focuses on understanding the role of the DNMT3A gene in the development of tissues affected by Tatton-Brown-Rahman Syndrome (TBRS), a condition linked to mutations in this gene. By studying patients who have a mix of normal and mutant cells, the researchers aim to uncover how these different cell types compete and influence tissue development. The approach involves analyzing the distribution and behavior of these cells in various tissues to determine how DNMT3A mutations impact overall health and development. This could provide valuable insights into the mechanisms behind TBRS and similar disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for patients with Tatton-Brown-Rahman Syndrome and related conditions.
How similar studies have gone: While the specific approach of studying somatic mosaicism in TBRS is relatively novel, similar research has shown promise in understanding other genetic disorders.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Waldvogel, Sarah Marie — Baylor College of Medicine
- Study coordinator: Waldvogel, Sarah Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.