Investigating how the lifespan of Lamin A/C proteins affects health and aging
Official title: Exploring modulation of Lamin A/C protein lifetime as a novel axis of regulation in heath and disease
Funded at University of California, San Francisco · NIH-11067834 · Data updated 2026-11-12
This study is looking at how certain proteins related to aging and heart health behave in different parts of the body, especially in people with conditions like progeria, to find ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $418,631 |
| NIH project number | 5R01AR084208-02 |
| Project ID | NIH-11067834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with laminopathies or those experiencing accelerated aging symptoms.
✕Less likely to help
Patients with conditions unrelated to laminopathies or accelerated aging may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of Lamin A/C proteins in cellular aging and various diseases, particularly those affecting the cardiovascular system. By examining how the lifetime of these proteins varies across different tissues, the study aims to uncover why certain tissues are more susceptible to mutations in the LMNA gene, which are linked to several syndromes known as laminopathies. The researchers will explore the effects of these mutations, especially in conditions like Hutchinson-Gilford progeria syndrome, where accelerated aging occurs due to a toxic form of Lamin A. Patients may benefit from insights gained about how to potentially modulate these proteins to improve health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases associated with accelerated aging and laminopathies.
How similar studies have gone: Previous research has shown promising results in understanding the role of nuclear proteins in aging and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Buchwalter, Abigail Lynn — University of California, San Francisco
- Study coordinator: Buchwalter, Abigail Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.