Investigating how the infrapatellar fat pad affects knee osteoarthritis after injury
Official title: Role of the Infrapatellar Fat Pad in the Development of Post-Traumatic Osteoarthritis Following Blunt Impact to the Knee Joint
Funded at University of Memphis · NIH-10654180 · Data updated 2026-11-12
This study is looking at how a specific fat pad in the knee might affect the development of arthritis after injuries, like those from sports or accidents, and it aims to find ways to help prevent or treat knee problems for people who have had these kinds of injuries.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Memphis NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $425,298 |
| NIH project number | 1R15AR082624-01 |
| Project ID | NIH-10654180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced blunt impacts to the knee, such as athletes or accident victims.
✕Less likely to help
Patients with pre-existing osteoarthritis unrelated to recent knee injuries may not benefit from this research.
What this research studies
This research focuses on understanding the role of the infrapatellar fat pad in the development of post-traumatic osteoarthritis (PTOA) following blunt impacts to the knee, such as those from sports injuries or accidents. The study utilizes animal models to observe how these impacts lead to cartilage damage and other joint issues. By examining the effects of removing the infrapatellar fat pad, the researchers aim to identify potential preventive measures against the progression of osteoarthritis. This could provide insights into new treatment strategies for patients who have experienced knee injuries.
Why it matters
Potential benefit: If successful, this research could lead to new preventive treatments for osteoarthritis in patients who have suffered knee injuries.
How similar studies have gone: Previous studies have shown promising results in similar approaches, indicating potential for success in this research.
Where this research is happening
-
University of Memphis
Memphis, United States Active
Researchers
- Principal investigator: Williams, John Leicester — University of Memphis
- Study coordinator: Williams, John Leicester
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.