Investigating how the INAFM2 gene affects cancer spread
Official title: Molecular mechanism of INAFM2 in metastasis
Funded at Georgetown University · NIH-10823958 · Data updated 2026-11-12
This study is looking at how a specific gene called INAFM2 affects the spread of Ewing sarcoma, a serious childhood cancer, by using zebrafish to see how changes in this gene impact cancer cells, with the hope of finding new ways to help kids with this disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $36,274 |
| NIH project number | 1F30CA287917-01 |
| Project ID | NIH-10823958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with Ewing sarcoma or other cancers that exhibit high levels of metastasis.
✕Less likely to help
Patients with non-metastatic cancers or those not affected by the INAFM2 gene may not benefit from this research.
What this research studies
This research focuses on understanding the role of the INAFM2 gene in the spread of cancer, particularly in Ewing sarcoma, a type of aggressive childhood cancer. Using advanced CRISPR technology, researchers will explore how changes in the INAFM2 gene influence cancer cell movement and metastasis in a zebrafish model. By analyzing patient tumor data, the study aims to uncover connections between INAFM2 expression levels and patient outcomes, potentially leading to new treatment targets for metastatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with metastatic cancers.
How similar studies have gone: Previous research has shown promising results using CRISPR technology to investigate cancer mechanisms, indicating potential for success in this novel approach.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Molotkova, Anna — Georgetown University
- Study coordinator: Molotkova, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.